Recessive dystrophic epidermolysis bullosa (RDEB) is a systemic disease of poor mucocutaneous basement membrane integrity downstream of bi-allelic pathogenic variants in COL7A1. Cutaneous clinical ...

Considered a disease of middle-aged and older adults until the late 20th century, type 2 diabetes has risen markedly ...

aDivision of Metabolism, Digestion and Reproduction, Imperial College London, London, UK bDepartment of Diabetes and Endocrinology, Imperial College Healthcare NHS Trust, London, UK cDepartment of ...

Research discoveries leading to the development of new pharmaceutical compounds are notoriously difficult to translate into clinical practice.1 Drug repurposing provides a strategy to identify ...

We write to highlight an urgent, yet preventable public health tragedy unfolding in the Ecuadorian Amazon. In May, 2025, eight Indigenous Achuar children from Taisha—an Amazonic village from the ...

PMI investment in supporting procurement and distribution of malaria control commodities would directly translate into ...

The current mpox outbreak in Sierra Leone is the largest ever recorded in the country and the first major epidemic caused by the clade IIb monkeypox virus in Africa. Since a public health emergency ...

In a single frame a photograph is a powerful way to tell a story and highlight an important issue. Each year The Lancet invites submissions for the Highlights photography competition and since 2009 we ...

Hybrid closed-loop insulin delivery systems are transforming the management of type 1 diabetes. Young children with type 1 ...

Obstructive sleep apnoea (OSA) is an important condition,1 but its role as a reversible cardiovascular risk factor has been ...

Michelle Monje is the Milan Gambhir Professor of Pediatric Neuro-Oncology at Stanford University, CA, USA, and a Howard ...

Lindgren and colleagues reported alarming health disparities in the Ten Americas study,1 which grouped populations based on race, ethnicity, and various geographical and sociodemographic factors. The ...