EMBO Press12h
Transcriptional enhancers in human neuronal differentiation provide clues to neuronal disorders
This study identifies 47,350 enhancers active in human neurons during differentiation and links some to genes involved in ...
The EMBO Journal5d
Coordination between ESCRT function and Rab conversion during endosome maturation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The endosomal pathway is essential for ...
EMBO Press6d
Haploinsufficient phenotypes promote selection of PTEN and ARID1A-deficient clones in human colon
Monoallelic loss of PTEN and ARID1A is identified in normal colonic epithelium. The resulting haploinsufficient phenotypes ...
The EMBO Journal6d
Type-2 innate signals are dispensable for skeletal muscle regeneration and pathology linked to Duchenne muscular dystrophy
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Immune responses play an integral role in ...
The EMBO Journal6d
Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile
Glioblastoma is one of the most treatment-resistant and lethal cancers, with a subset of self-renewing brain tumour stem cells (BTSCs), driving therapy resistance and relapse. Here, we report that ...
The EMBO Journal6d
Reprograming of the ubiquitin ligase Ubr1 by intrinsically disordered Roq1 through cooperating multifunctional motifs
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. One way cells control the speed and ...
The EMBO Journal6d
Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. As a common cause of liver cirrhosis, ...
The EMBO Journal7d
Immune cells adapt to confined environments in vivo to optimise nuclear plasticity for migration
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cells navigating in complex 3D ...