Last November, Johnson & Johnson shelved posdinemab. Top-line data from its Phase 2b trial had suggested the anti-tau antibody failed to slow deterioration in people with early-stage Alzheimer’s ...
The MAPT haplotypes H1 and H2 are defined by a large inversion polymorphism on chromosome 17. The HI haplotype has been consistently linked to risk for several neurodegenerative diseases, particularly ...
It has been suggested that differences in mouse and human tau may partially underlie the difficulty in modeling Alzheimer’s disease in mice (see Alzforum webinar). In this knock-in model, the entire ...
This widely used tauopathy model was developed at the University of Pennsylvania School of Medicine by Virginia Lee, John Trojanowski, and colleagues. As first reported in 2007 on a mixed background, ...
Focused ultrasound with microbubbles is a noninvasive procedure that transiently opens the blood-brain barrier (BBB) using low-intensity sound waves. The openings reseal within 24 hours. Using MRI to ...
This transgenic (Tg) mouse overexpresses a mutant form of Lrrk2 (G2019S) using a bacterial artificial chromosome (BAC) (Li et al., 2010). Transgene expression is driven by the mouse Lrrk2 promoter ...
We have developed this special section of the Alzforum website to provide a resource for all who share an intense interest in familial early onset AD (eFAD). We have created this series of articles ...
Sensory Stimulation Systems, and GENUS, refer to a noninvasive procedure, i.e., a "digital therapeutic," being developed by Cognito Therapeutics. The company developed a wearable GammaSense ...
Score another one for amyloid immunotherapy. The anti-pyroglutamated amyloid antibody donanemab has posted positive top-line results in the Phase 3 Trailblazer-Alz2 study, according to an Eli Lilly ...
For 30 years, APOE4 has ranked as the strongest genetic risk factor for Alzheimer’s disease, with two copies boosting the odds up to 15-fold. Now, scientists argue that people with two APOE4 alleles ...
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