Here are the Bills' toughest opponents in 2025. 5. Houston Texans This spot was a toss up between the Tampa Bay Buccaneers and the Texans.

Buffalo Bills 2025 opponents Buffalo will have nine home games and eight away games in the 17-game regular season. In odd-numbered years, the AFC teams get an extra home game.

The Bills opponents for 2025 have been announced. Buffalo will have 9 home games in 2025. The 2025 NFL Draft has come and gone the Buffalo Bills are closer to their 2025 regular season opener than ...