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High-frequency oscillatory ventilation may reduce the incidence of bronchopulmonary dysplasia in neonatal respiratory distress syndrome

1. High-frequency oscillatory ventilation (HFOV) may reduce the incidence of bronchopulmonary dysplasia (BPD) compared with conventional mechanical ventilation (CMV) in infants born at 34 weeks’ ...
2 Minute Medicine

NeoCol trial: Neoadjuvant chemotherapy does not improve disease-free survival in patients with locally advanced colon cancer

Neoadjuvant capecitabine-oxaliplatin chemotherapy did not improve three-year disease-free survival compared to upfront surgery in locally advanced colon cancer. 2. An exploratory subgroup analysis ...
2 Minute Medicine

David Painter, MD

1. Neoadjuvant capecitabine-oxaliplatin chemotherapy did not improve three-year disease-free survival compared to upfront surgery in locally advanced colon cancer. 2.
2 Minute Medicine

Sivelestat may reduce the risk of acute respiratory distress syndrome in adults undergoing cardiac surgery

Sivelestat significantly reduced the incidence of postoperative acute respiratory distress syndrome (ARDS) compared to ...
2 Minute Medicine

New guidelines limit hypertension treatment in adults over 65

In this cross-sectional study, 11.4% of adults aged 65 years or older with untreated stage 1 hypertension, predominantly ...
2 Minute Medicine

Burr hole craniotomy for chronic subdural hematoma under local anesthesia may reduce risks of postoperative delirium compared to general anesthesia

In patients with chronic subdural hematoma (cSDH) requiring burr hole craniotomy, operation under local anesthesia (LA) was safe, well-tolerated, and associated with significantly reduced risks of ...
2 Minute Medicine

Smallpox therapy tecovirimat not efficacious in treating clade II mpox

In this phase 3, randomized, placebo-controlled trial, an antiviral medication approved for treating smallpox (tecovirimat) did not accelerate clinical resolution of mpox compared to placebo. 2.
2 Minute Medicine

Oral infigratinib boosts growth velocity in achondroplasia study

Oral infigratinib achieved the highest growth velocity reported to date in a randomized achondroplasia trial, growing 2.10 cm ...
2 Minute Medicine

Delivery of evidence-based interventions for alcohol misuse in the emergency department is low

Alcohol misuse among older adults is common but the delivery of evidence-based interventions such as referral services and pharmacotherapy remains low in the emergency department (ED). Evidence Rating ...
2 Minute Medicine

2 Minute Medicine Rewind March 16, 2026

High-Frequency Oscillation vs Mechanical Ventilation for Neonatal Acute Respiratory Distress Syndrome 1. High-frequency ...
2 Minute Medicine

Psilocybin in combination with cognitive behavioural therapy may improve smoking abstinence compared to nicotine patches

In this randomized controlled trial, psilocybin combined with cognitive behavioural therapy (CBT) is associated with significantly higher smoking abstinence at 6 months compared to the use of a ...
2 Minute Medicine

Glucagon-like peptide-1 receptor agonists are associated with reduced risk of developing substance use disorders

Use of glucagon-like peptide-1 (GLP-1) receptor agonists was associated with reduced risk of developing substance use disorders among US veterans with type 2 diabetes. Evidence Rating Level: 2 (Good) ...