Objective To evaluate the efficacy and safety of an oral selective tyrosine kinase 2 (TYK2) inhibitor, deucravacitinib, in patients with active psoriatic arthritis (PsA). Methods In this double-blind, ...

Objectives To evaluate the efficacy and safety of upadacitinib, a Janus kinase inhibitor, in patients with active ankylosing spondylitis (AS) with an inadequate response (IR) to biological ...

Objectives Bone remodelling is a highly dynamic process dependent on the precise coordination of osteoblasts and haematopoietic-cell derived osteoclasts. Changes in core metabolic pathways during ...

Background The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological ...

2 Clinical Development, Antares Pharma Inc, Ewing, New Jersey, USA 3 Medical Department, Antares Pharma Inc, Ewing, New Jersey, USA Objective To compare the relative bioavailability, safety and ...

Objective To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of ...

Correspondence to Professor Shiquan Sun, Xi'an Jiaotong University, Xi'an, Shaanxi, China; sqsunsph{at}xjtu.edu.cn; Professor Guangdun Peng, Chinese Academy of Sciences, Guangzhou, Guangdong, China; ...

12 Universidade de Lisboa, Centro Académico de Medicina de Lisboa, Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Lisboa, Portugal 13 University of Catania, ...

Chimeric antigen receptors (CARs) are synthetic proteins designed to direct an immune response toward a specific target and have been used in immunotherapeutic applications through the adoptive ...

1 Columbia University Irving Medical Center, Rheumatology, New York, United States of America 2 Vanderbuilt University Medical Center, Medicine, Nashville, United States of America 3 University of ...

5 CNRS, INSERM, Institut Necker Enfants Malades-INEM, F-75015 Paris, France; Faculté de Médecine, University of Paris City, Paris, France Objectives Alterations in tryptophan (Trp) metabolism have ...

Background An increased risk of malignancy was reported in patients with Systemic Lupus Erythematosus (SLE) [1-3]. Objectives To estimate the prevalence of cancer in a Portuguese cohort of patients ...