Recent guidelines recommend consideration of the use of oral edoxaban or rivaroxaban for the treatment of venous thromboembolism in patients with cancer. However, the benefit of these oral agents ...

This article reviews the progress made during the past decade in elucidating the pathophysiological mechanisms of hereditary angioedema and the subsequent development of targeted treatments for ...

Attention deficit–hyperactivity disorder (ADHD) is characterized by hyperactivity and impulsivity, by inattention, or by a combination of hyperactivity, impulsivity, and inattention that is ...

Pulmonary hypertension is a syndrome characterized by marked remodeling of the pulmonary vasculature and a progressive rise in the pulmonary vascular load, leading to hypertrophy and remodeling of ...

Phenotypes Acute hepatic necrosis, serum enzyme elevations, sinusoidal obstruction, acute fatty liver, nodular regeneration Acute hepatocellular hepatitis, mixed or cholestatic hepatitis, bland ...

In 1928, Sir Alexander Fleming discovered that the active component of a penicillium fungus had the capacity to kill bacteria in a petri dish, and he named it penicillin. In 1945, Fleming, Florey ...

Hormone absence or inactivity is common in congenital disease, but hormone antagonism remains controversial. Here, we characterize two novel homozygous leptin variants that yielded antagonistic ...

Shown are the phases of rupture and healing of an atherosclerotic plaque. The cross-section of a plaque in Panel A shows a central core containing lipids and necrotic debris (yellow) and ...

Interactions between cardiac and kidney diseases have been classified as cardiorenal syndromes. A current classification 10 includes five types of cardiorenal syndromes: acute cardiac impairment ...

Aldosterone synthase controls the synthesis of aldosterone and has been a pharmacologic target for the treatment of hypertension for several decades. Selective inhibition of aldosterone synthase ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Next-generation sequencing has enabled precision therapeutic approaches that have improved the lives of children with rare diseases. Congenital diarrhea and enteropathies (CODEs) are associated ...