The Interstate 81 northbound Exit 29N off-ramp in the Town of Cicero will be closed from 9 p.m. to 4 a.m. on weeknights ...

The southbound lanes of Interstate 81 in Smyth County were temporarily closed on Wednesday evening following a single-vehicle ...

A crash on Interstate 81 Northbound tied up traffic in both directions Sunday afternoon. The crash was near the 74 milepost ...

The on-ramp from Sunset Avenue I-81 North in Syracuse will be closed from 7 a.m. to 3 p.m. Tuesday for the removal of the ...

The Department of Transportation said that Interstate 81 Northbound Exit 29N (State Route 481 North/Oswego) will be closed to ...

The Pennsylvania Department of Transportation announced that maintenance to a digital message board is scheduled on ...

A tractor trailer crash at mile marker 237 on Interstate 81 in Rockingham County is causing delays on the roadway Tuesday.

Interstate 81 hasn’t had significant improvements since it was built in the 50s. Since then, we’ve seen increased traffic, vehicle sizes and more trucks hauling freight.

POTTSVILLE, Pa. (CBS) — Interstate-81 in Schuylkill county reopened overnight after a deadly pileup on Monday. The crash has now claimed the lives of six people and left more than a dozen injured.

The future of Interstate 81 through downtown Syracuse has been talked about for more than a decade. This week, a group promoting strong urban cores highlighted the project, calling it a "watershed ...