As the markets for weight-loss drugs develop, pharma companies are having to adapt in search of the next big thing.

Compounded weight loss drugs have been mostly off the market for about a month, but the weight loss drug industry remains as unsettled as ever. Earlier this week, Novo Nordisk tore up a partnership with the telehealth storefront Hims & Hers Health,

Some new medications in development are also trying to solve for a persistent side effect of existing drugs: Patients who lose fat also tend to lose muscle. This can be particularly dangerous for older adults because it makes them more likely to fall and can worsen osteoporosis.