Animals on the early branches of the tree of life, such as jellyfish and sea sponges, defy the usual conventions of aging. Some show abilities to regenerate damaged or missing tissues, halt or reverse ...

The potential protective effect of sirtuin enzymes in age-related diseases, including cardiovascular diseases, remains an area of intense investigation. Now, researchers has determined that sirtuin 1 ...

The human heart is a remarkable muscle, beating more than 2 billion times over the average life span. But the heart's efficiency can decrease over time. One major contributor to this decreased ...

Proteins undergo a diverse array of chemical modifications that modulate their activity. The enzymes that add and remove these modifications are therefore key decision-makers in signalling cascades.

Researchers found that the gene sirtuin 6 (SIRT6) is responsible for more efficient DNA repair in species with longer lifespans. The research illuminates new targets for anti-aging interventions and ...

Sirtuin genes and the proteins they encode were already linked to longevity in yeast. Now, a previously overlooked member of the family has excited researchers who study aging At last, a member of the ...

Sirtuins are a family of anti-aging proteins that help regulate cellular lifespan, metabolism, and resistance to stress. The potential protective effect of these sirtuin enzymes in age-related ...

Jellyfish, sea sponges, amoebas and other animals on the early branches of the tree of life defy conventional aging. A new study reveals diversity of proteins called sirtuins in these animals compared ...