Glucocorticoids (GCs) induce apoptosis in certain lymphoid cells and play an important role in the treatment of childhood acute lymphoblastic leukemia (ALL) and other lymphoid malignancies. 1 This ...

Synthetic biochemistry seeks to engineer complex metabolic pathways for chemical conversions outside the constraints of the cell. Establishment of effective and flexible cell-free systems requires the ...

St. Jude Children's Research Hospital scientists have determined how a protein's disordered region serves as a molecular rheostat to help regulate cell survival. The survival drama is played out ...

Researchers have found a switch that regulates the activity of HNF1A, a gene that causes diabetes. The study highlights potential new vulnerabilities in the disease and could lead to the development ...

Although drugs that target the brain's serotonin system are in wide use for treating depression, the basic biological mechanism by which they help alleviate symptoms is poorly understood. Now, new ...

Rheostat Therapeutics, a young biotech firm focused on treatments for neurodegeneration, cognition, and rare diseases, secured $23 million in its first formal round of funding. Rheostat is developing ...