Microglial activation is a determining factor that allows amyloid-beta accumulation to drive reactive astrogliosis, amplifying inflammatory responses in the brain. This was the conclusion of a study ...

New research has identified that neuroinflammation driven by microglia (immune cells in the brain) is a primary underlying ...

A study by researchers from Fujita University reveals that hypernatremia enhances NFAT5 and NO production in microglia and minocycline mitigates this response. The image above is a schematic showing ...

Neurodegenerative diseases, traditionally viewed as driven by neuronal decline, are increasingly recognized to involve significant immune dysfunction within and outside the central nervous system (CNS ...

Move over, amyloid, reactive astrocytes and activated microglia may be the main drivers of the Alzheimer’s disease pathological cascade. In the November 6 Nature Neuroscience, scientists led by Pedro ...

“These are the first data to link ASC speck assembly, NLRP1 inflammasome activation, and alpha-synuclein aggregation in neurons of Parkinson’s disease patients,” said Stephen C. Glover, ZyVersa’s ...

A study in mice suggests infantile amnesia is not a failure of memory, but a developmentally useful process guided by brain ...

The idea that infiltrating T cells contribute to a neurodegenerative environment in aging and in Alzheimer’s disease has gotten another boost. In the June 27 Nature Neuroscience, scientists led by ...