Mutations in the proapoptotic BAX gene are associated with defective DNA mismatch repair and altered tumor growth rates in human colon cancers The metabolic fragility of cancer cells is magnified with ...

Nutrient deprivation inhibits mTORC1 and activates AMPK, which then dephosphorylates or phosphorylates ULK1 at different sites, leading to the activation of the ULK complex and initiation of the ...

Recent studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like other coronaviruses, hijacks various host cell machinery such as autophagy for replication and ...

Undruggable targets typically refer to a class of therapeutic targets that are difficult to target through conventional methods or have not yet been targeted, but are of great clinical significance.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease (COVID-19), continues to ravage across the globe. To date, more than 64 million people ...