Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

Bacterial replisomes often dissociate from replication forks before chromosomal replication is complete. To avoid the lethal consequences of such situations, bacteria have evolved replication restart ...

Fig. 4: The process of establishment of pre-RCs at an S. cerevisiae origin in which the B2 domain is separated from the A and B1 origin elements. This Review focuses on the first step in eukaryotic ...

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

Seventy years ago, two male scientists, Francis Crick and James Watson, proclaimed they had discovered the secret of life: the structure of DNA. Since then, history has acknowledged how Rosalind ...

In the middle of the 20th century, accumulating data suggested that DNA carries life’s genetic information. Biochemists around the world raced to determine its structure. The competition led to some ...

Cold sore virus takes over human DNA within just one hour, study finds - Study is first to prove that herpes virus reshapes ...

“The laws of inheritance are quite unknown,” Charles Darwin acknowledged in 1859. The discovery of DNA’s shape altered how we conceived of life itself. The X-ray crystallography by Rosalind Franklin ...