Nature

RAS cancer biology (mutations, signaling, etc.) plus emerging RAS-directed therapeutic advances and new horizons

The RAS family commonly drives the growth and survival of human cancers. Mutations in KRAS, NRAS, and HRAS occur in approximately 20% of all human cancers, including solid tumors, such as pancreatic, ...

Motor protein discovery in fruit flies may unlock neurodegenerative secrets

Scientists have long known that inherited neurodegenerative disorders, including Alzheimer's, Parkinson's or motor neuron ...
Labroots

GoT-ChA! - Assessing How Mutations Affect DNA Structure in Single Cells

Scientists have created a new technique that can assess how mutations in the genome influence the packaging of DNA in cells. The genome is massive, and has to be carefully wrapped around proteins so ...
Hosted on MSN

Rare mutations in three genes may disrupt neuron communication to cause ADHD

Researchers have identified specific genes containing rare mutations that significantly increase the likelihood of developing attention deficit hyperactivity disorder. These findings, published in the ...
ascopubs.org

Epidermal Growth Factor Receptor Mutations in Non–Small-Cell Lung Cancer: Implications for Treatment and Tumor Biology

Epidermal Growth Factor Receptor Mutations in Non–Small-Cell Lung Cancer: Implications for Treatment and Tumor Biology. If you have the appropriate software installed, you can download article ...
BioTechniques

Novel tool for detecting hidden genetic mutations

A graph-based computational tool for detecting previously invisible genetic mutations has been developed. Researchers at the University of California, Los Angeles (UCLA; USA) and the University of ...
BioTechniques

Novel technique detects early DNA mutations

A new long-read sequencing technique has helped researchers investigate how DNA mutations arise in a variety of contexts. A collaboration of researchers led by NYU Langone Health and NYU Grossman ...

Phages and bacteria accumulate distinctive mutations aboard the International Space Station

In a new study, terrestrial bacteria-infecting viruses were still able to infect their E. coli hosts in near-weightless ...
Labroots

Revealing the Links Between RPA Mutations & Disease

Our DNA is compacted and arranged into chromosomes, most of which are shaped like X’s. The ends of the chromosomes' arms are protected with caps known as telomeres. Telomeres are made up of highly ...
WebMD

MTHFR Gene Mutation: Tests, Symptoms, and Treatment

What Is the MTHFR Gene Mutation? The MTHFR gene mutation is a variation in the MTHFR gene. This gene normally tells your body how to make the MTHFR protein. You need this protein to process folate, ...

New Data Underscoring Ability of Leapfrog Bio's OncoSLX Platform to Identify Drug Retargeting Opportunities for Treating Cancer Published in Nature Portfolio Journal

Study highlights importance of cancer driver biology in translating results from lab to patients -- -- Findings validate proprietary OncoSLX Platform (TM), a pharmacogenetic approach that captures the ...