People inherit two copies of each gene — one from each parent — an evolutionary fail-safe to ensure survival even when one of them doesn’t function. Likely not, according to the findings of a new ...

A study led by Harvard Medical School researchers shed new light on how even a single defective copy of the tumor-suppressor BRCA1 gene can increase patients’ risk of developing breast cancer.

Researchers at the University of Cambridge have created the world's largest catalog of human breast cells, which has revealed early cell changes in healthy carriers of BRCA1 and BRCA2 gene mutations.

Researchers from The University of Texas MD Anderson Cancer Center identified a new role for heat shock protein 90 (HSP90) in cancer predisposition and treatment resistance.

Research reveals that around 20 per cent of all cases of the most severe form of breast cancer may arise from the small group of normal tissue cells carrying an epimutation of a specific gene.

Hope is on the horizon for patients with aggressive, inherited breast cancers. A recent clinical trial, led by researchers at Cambridge University, explored the effects of combining chemotherapy with ...

Germline pathogenic variants (gPVs) occur in a subset of patients with ovarian cancer, with the highest prevalence among those with Ashkenazi Jewish ancestry, followed by Asian and Hispanic patients, ...

Mutations in BRCA1 do not appear to contribute significantly to the risk of prostate cancer progression, according to DNA test results from 450 prostate cancer specimens. The findings suggest that ...

The authors do not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and have disclosed no relevant affiliations beyond their ...

BRCA gene expression is induced at the G1/S boundary in cultured cell lines (Gudas et al., 1996; Vaughn et al., 1996a,b) and primary tissues (Blackshear et al., 1998; Rajan et al., 1996), and the ...

ComingSoon can exclusively reveal the trailer for Love, Danielle. Love, Danielle is a new dramedy movie about a woman who tests positive for a BRCA1 gene mutation, which then puts her at high risk of ...