Tweaking electronic properties of starting materials can help bypass an obstacle to elusive bicyclic drug scaffold ...

The term aromaticity is a basic, long-standing concept in chemistry that is well established for ring-shaped carbon compounds. Aromatic rings consisting solely of metal atoms were, however, heretofore ...

Arynes are highly reactive organic intermediates featuring a triple bond within an aromatic ring. Their strong reactivity enables them to form bonds with a wide range of functional groups, making them ...

Replacing a carbon atom in an aromatic ring with a nitrogen atom is one of those exercises that’s easy to do on paper with a pencil and eraser but tough to accomplish in a reaction flask. Chemists ...

Electrophilic aromatic substitution (EAS) constitutes a fundamental class of reactions in which an electrophile replaces a hydrogen atom on an aromatic ring. The process typically proceeds via initial ...

Aromatic modules are characterized by a ring shape and a special bonding situation that allows electrons to move freely around the ring if positioned in a magnetic field. The increased stability ...

Nucleophilic aromatic substitution reactions constitute a fundamental class of transformations in organic chemistry, enabling the replacement of a leaving group on an aromatic ring by a nucleophile.