Chargers vs. 49ers game will air on CBS Los Angeles. It can also be streamed on NFL+ for subscribers. Streaming options for the game include the ESPN app, ESPN Unlimited and Fubo, which offers a free trial. The game will begin at 8:30 p.m. ET / 5:30 p.m. PT.

The San Francisco 49ers resume Week 3 of the 2025 NFL preseason hosting the Los Angeles Chargers tonight. Start time, where to watch, stream and NFL schedule.

Brock Purdy, Christian McCaffrey, Trent Williams, Nick Bosa, Fred Warner, George Kittle and Deommodore Lenoir should all be sitting out. A handful of potential starters may suit up to help solidify their status atop the depth chart, but that core group should strictly be focused on the regular season opener Sept. 7.