WASHINGTON (AP) — After a weekend of setbacks, the Senate will try to sprint ahead Monday on President Donald Trump’s big bill of tax breaks and spending cuts despite a series of challenges, including the sudden announcement from one GOP senator that he won’t run for reelection after opposing the package over its Medicaid health care cuts.

Senate Republicans can afford to lose no more than three of their own votes on the bill, but two already are opposed and others remained undecided.