Nathan Lukes initiated the scoring with a two-run homer in the fifth, while Bo Bichette contributed with an RBI single in the eighth. Vladimir Guerrero Jr. and George Springer each added RBI singles, and pinch-hitter Jonatan Clase delivered a two-run double in the seventh, but it was him replacing Anthony Santander that caused concern among fans.

After dropping their last two series at home, the Toronto Blue Jays were looking to turn things around while welcoming a strong opponent in the San Diego Padres.

The San Diego Padres dropped their fifth straight game -- a 14-0 shutout loss to the Toronto Blue Jays on Wednesday night.

Daulton Varsho hit a grand slam in a seven-run eighth inning and the Toronto Blue Jays routed the San Diego Padres 14-0 on Wednesday night

Preview the May 22 matchup between the San Diego Padres and Toronto Blue Jays with odds over/under, game spread, betting lines and more.

By losing 14-0 to the Toronto Blue Jays on Wednesday, the San Diego Padres' five-game losing streak reached a low point not seen since the franchise's origins.

Anthony Santander and Vladimir Guerrero Jr. homered, Chris Bassitt and three relievers combined on a five-hitter and the Toronto Blue Jays beat the San Diego Padres 3-0.